Session 2A: Inhalation toxicity – drivers of toxicity

Session chairs

Tobias Stöger, Group leader, Helmholtz Zentrum München, German Research Center for Environmental Health, Germany,

Håkan Wallin, Group leader, Department of Chemical and Biological Work Environment, the National Institute of Occupational Health (STAMI), Norway,

Session abstract

Inhaled nanoparticles are known to deposit particularly effective in the alveolar periphery of the lungs where they escape a fast removal by mucociliary clearance. Scavenged by alveolar macrophages or residing on the fragile respiratory surface nanoparticles have been shown cause irritations to interacting cells and cause innate immune responses depending on their material specific toxicity. Within the various potential toxicological outcomes the inflammatory response is often considered crucial for pulmonary and extra-pulmonary health effects. In this session we would like to focus on processes and pathways recently discussed to represent relevant drivers for the toxicity of inhaled nanoparticles.

Session program

  • The cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles – Invited presentation
    François Huaux
  • Macrophage responses to particles – Invited presentation
    Tobias Stöger
  • The role of interleukin-1 cytokine in the fibrotic responses of multi-walled carbon nanotubes injected into the pleural cavity
    Shan Zienolddiny
  • Inhalation toxicity of 5–10 nm cerium dioxide nanoparticles
    Rachel Smith