Tobias Stöger, Group leader, Helmholtz Zentrum München, German Research Center for Environmental Health, Germany, email@example.com
Håkan Wallin, Group leader, Department of Chemical and Biological Work Environment, the National Institute of Occupational Health (STAMI), Norway, firstname.lastname@example.org
Inhaled nanoparticles are known to deposit particularly effective in the alveolar periphery of the lungs where they escape a fast removal by mucociliary clearance. Scavenged by alveolar macrophages or residing on the fragile respiratory surface nanoparticles have been shown cause irritations to interacting cells and cause innate immune responses depending on their material specific toxicity. Within the various potential toxicological outcomes the inflammatory response is often considered crucial for pulmonary and extra-pulmonary health effects. In this session we would like to focus on processes and pathways recently discussed to represent relevant drivers for the toxicity of inhaled nanoparticles.
- The cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles – Invited presentation
- Macrophage responses to particles – Invited presentation
- The role of interleukin-1 cytokine in the fibrotic responses of multi-walled carbon nanotubes injected into the pleural cavity
- Inhalation toxicity of 5–10 nm cerium dioxide nanoparticles