Session 2B: Nanomaterial characterization in toxicology – Reactivity, dissolution, and biomolecule interactions

Session chairs

Iseult Lynch, Professor at School of Geography, Earth and Environmental Sciences, University of Birmingham, United Kingdom

Trine Berthing, Post.doc. at the National Research Centre for the Working Environment (NRCWE), Denmark, trb@nrcwe.dk

Session abstract

Most of the challenges in interpretation of data regarding the impacts of NMs on living systems to date have resulted from insufficient characterisation of the NMs dispersions under the exposure conditions and over the exposure timeframe.  Scientists are increasingly recognising that NMs age during storage, so characterisation must be performed at the time exposure experiments are performed also.  Approaches that link specific physico-chemical characteristics with biological and toxicological impacts, and to Adverse Outcome pathways, are desperately needed.  Differentiation between intrinsic properties, which result from the material composition and structure, and extrinsic properties which derive from its interactions with the surrounding medium and biomolecules, is one such approach.  Methods that focus on the hydration layer immediately in contact with NMs surfaces are emerging, and shed new light on the sources of particle reactivity, and mechanisms of dissolution and interaction with biological macromolecules.  For this session, we invite contributions addressing any aspect of NMs characterisation for toxicological assessment, including methodologies and approaches to focus specifically on the interfacial properties and novel changes resulting from the highly reactive surface molecules.

Session program

  • Nanoparticle behavior variability: sources, characterization needs, and best practices – Invited presentation
    Donald R Baer
  • The importance of characterisation of bionanointeractions in NM (eco)toxicity assessment: new approaches and insights – Invited presentation
    Iseult Lynch
  • Dissolution and transformation of Zn-containing nanomaterials in artificial lung fluids
    Aleksandr Stefaniak
  • Evaluation of intrinsic versus cell-based oxidative properties of nanomaterials and associated oxidative stress responses using multiple assays
    Bryan Hellack