Session 3A: Reprotoxicity

Session chairs

Flemming R. Cassee, Senior Scientific Advisor at the Dutch National Institute for Public Health and the Environment (RIVM), and professor in Inhalation Toxicology at the Institute for Risk Assessment Studies of the Utrecht University, The Netherlands

Karin Sørig Hougaard, Senior Researcher at the National Research Centre for the Working Environment (NRCWE), Denmark,

Session abstract

Studies on developmental and reproductive toxicity of nanomaterials have lagged behind other types of hazard assessment. This rather unexplored area has gained significantly more interest in the past few years. Experimental and epidemiological studies suggest that maternal airway exposure to small particles can cause adverse effects in the developing fetus, for example related to functional impairments in life after birth. Recent studies also indicate that the male reproductive function is can be affected by particle exposures. In this workshop, we aim to present the latest scientific information on developmental and reproductive effects of airborne particles.

Session program

  • Engineered nanomaterial inhalation during gestation: Ramifications on uterine microvascular function, the fetal genome and cardiac transcriptome – Invited presentation
    Timothy Robert Nurkiewicz
  • Maternal exposure to diluted diesel engine exhaust alters placental function of the first and second generation in rabbit model – Invited presentation
    Anne Couturier-Tarrade
  • Induction of behavioral changes and astrogliosis in the brain of offspring mice following maternal inhalation of carbon black nanoparticle
    Atsuto Onoda
  • Pulmonary exposure to metallic nanoparticles during pregnancy irreversibly impairs lung development of the offspring
    Sophie Lanone
  • In utero exposure to ultrafine particles induces 11-hydroxysteroid dehydrogenase type 2-related placenta stress in mice
    Andrea De Vizcaya-Ruiz
  • Effects of pulmonary exposure to nano particles on male reproductive function
    Astrid Skovmand