Hanna Karlsson, PhD, Associate Professor at Institute of Environmental Medicine, Karolinska Institutet, Sweden, Hanna.L.Karlsson@ki.se
Andrea Hartwig, Professor, Karlsruhe Institute of Technology (KIT), Institute of Applied Biosciences, Karlsruhe, Germany, firstname.lastname@example.org
Some nanomaterials can dissolve and thereby release potentially toxic metal ions. This can take place in both extra- and intracellular compartments and is affected by various parameters including pH and composition of the media. Soluble or partly soluble metal oxides, such as ZnO and CuO, have often shown high acute toxicity when compared to other more stable nanomaterials. Furthermore, for silver nanoparticles the release of silver ions is considered important for toxicity. This session will discuss toxicity of soluble and partly soluble nanomaterials. Important aspects include nanoparticle vs ion effects, the “Trojan-horse mechanism”, dissolution assessment and speciation of released ions, genotoxicity and role of dissolution in risk assessment of nanomaterials.
- Soluble nanoparticles – toxicity, dissolution testing and risk assessment – Invited presentation
- Use of gene expression profiling to assess the impact of partly soluble metal-based nanoparticles on genomic stability – Invited presentation