Session 4A: New hazard endpoints of nanomaterial exposure

Session chairs

Roel Schins, PhD, Head of Research Group, Leibniz Research Institute for Environmental Medicine (IUF), Germany,

Peter Moller, Professor, Department of Public Health, University of Copenhagen, Denmark,

Session abstract

The list of putative health endpoints of nanomaterial exposure has been extended beyond the classic hazards related to cardiopulmonary effects. This reflects both novel observations in nanotoxicology as well as putative relationships between nanomaterial exposure and health effects based on associations in air pollution epidemiology. One such association is neurotoxicity and risk of neurodegenerative disorders, including Alzheimer’s disease. Likewise, molecular epidemiological observations between aging, telomere shortening and risk of cardiovascular diseases have prompted novel research of relationships between particle exposure and telomere attrition in cell cultures and animal models. Interestingly, the risks of cancer, cardiovascular disease and neurodegenerative disorders increase with age. In this context, the effects attributed to particle exposure can be interpreted as a phenomenon related to accelerated aging. The session on new hazard endpoints of nanomaterial exposure seeks to focus on novel observations of toxicological effects of nanomaterials in the context of physiological and pathological aging and cellular senescence.

Session program

  • Telomere length as a new hazard measure in nanoparticle toxicology – Invited presentation
    Peter Møller
  • Effect of age, diet, rat strain, and particle exposure on lung and peripheral blood mononuclear cell (PBMC) telomere regulation and length
    Aaron Erdely
  • Cellular senescence induced by combustion-derived nanoparticles in endothelial cells and lung epithelial cells
    Klaus Unfried
  • Effects of nanoparticles in the 5xFAD mouse model of Alzheimer’s Disease – Invited presentation
    Roel Schins
  • Integrated in vitro neurotoxicity testing: an approach to improve hazard assessment of inhaled substances
    Harm J Heusinkveld
  • Thrombotic potential of intravenous engineered nanoparticles
    Jennifer Bridget Raftis
  • Acute fine particulate matter exposure reduces heart rate variability in road maintenance workers
    Michael Riediker