Session 5A: In vivo models of hazard

Session chairs

Alison Elder, Associate Professor at the University of Rochester Medical Center, University of Rochester, Rochester, NY, USA

Kristina Bram Knudsen, Post.doc. at the National Research Centre for the Working Environment (NRCWE), Denmark, kbk@nrcwe.dk

Session abstract

Nanotechnology promises to meet significant societal needs in building materials, electronics, and biomedicine.  The constant and rapid production of new nanomaterials combined with high production volumes for some has led to concerns regarding the hazards that they might pose to occupational and environmental health.  The use of in vivo models to address toxicological concerns is challenged by knowledge gaps related to exposure and dose characterization, the appropriate implementation of screening strategies to reduce and refine animal use, the physicochemical properties that are of greatest concern with respect to human health, and a poor understanding of target organs and mechanisms of toxicological response that can inform human risk assessment.  This session will address these knowledge gaps in order to advance the goal of responsible nanomaterial production, use, and disposal.

Keywords: in vivo; physicochemical properties; exposure-dose-response analysis; mechanisms

Session program

  • Physicochemical predictors of MWCNT-induced pulmonary histopathology and toxicity 1 year after pulmonary deposition of 11 different MWCNT in C57BL/6N mice – Invited presentation
    Kristina B Knudsen
  • Effects in the lungs following inhalation exposures to nanoparticle-containing slurries used in semiconductor manufacturing – Invited presentation
    Alison Elder
  • Characterization of pulmonary toxicity following acute exposure to a boron nitride nanotube suspension
    Aaron Erdely
  • The influence of the redox activity of inhaled nano-sized cerium dioxide on respiratory, immune, cardiovascular and neurological effects in various mouse models
    Flemming R Cassee
  • Lung remodeling after pulmonary exposure of mice to cerium oxide nanoparticles – role of autophagy
    Sophie Lanone
  • Carbon nanoparticle and lung interaction is crucial for systemic effects: Lessons learnt from inhalation versus intra-arterial infusion exposure studies in mice
    Koustav Ganguly